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Bulk Alemtuzumab Biosimilar – Research Grade
Product Benefits:
ichorbio’s Alemtuzumab Biosimilar – Research Grade is manufactured in a cGMP compliant facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Size:
ichorbio’s research grade alemtuzumab biosimilar is available in the following sizes:5mg, 10mg, 20mg, 50mgichorbio regularly manufactures bulk multi-gram amounts of our alemtuzumab biosimilar – please contact us for pricing.
Target:
CD52
Clone:
n/a
Isotype:
IgG1 kappa
Other Names:
Campath-1 antigen, Cambridge pathology 1 antigen, HE5
Host:
Humanized
Species Reactivity:
Human
Specificity:
Detects human CD52. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Alemtuzumab.
Purification Method:
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:
Alemtuzumab biosimilar is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) directed against the 21-28 kD cell surface glycoprotein, CD52, is an IgG1 kappa antibody with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody. The alemtuzumab biosimilar has an approximate molecular weight of 150 kD and is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium.
Concentration:
1.0 – 5.0 mg/ml
Formulation:
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity:
>95% by SDS-PAGE and HPLC
Endotoxin:
≤ 0.75 EU/mg as determined by the LAL method
Storage:
Alemtuzumab Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:
Functional Assays
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Use:
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